Atezolizumab and Bevacizumab in Therapy for Patients with Hepatocellular Carcinoma in Real Clinical Practice
نویسندگان
چکیده
Randomized clinical trials and actual practice differsignificantly. Evidence-based medicine develops new agents referring to, primarily, pharmaceutical findings, preclinical studies and, most importantly, randomized trials. Hepatocellular carcinoma is the common primary malignancy of liver, one main causes fatal outcomes among cancer patients worldwide, including in Asia-Pacific region, with an estimated 800,000 deaths annually. For more than 10 years, sorafenib, a tyrosine kinase inhibitor, was only authorized treatment for advanced hepatocellular carcinoma. The next stage development drug therapy involved immune checkpoint inhibitors. combination atezolizumab bevacizumab phase III trial (IMbrave150) improved carcinoma, such as overall survival progression-free (6.8 versus 4.3). paper presents combination, demonstrates comparable data on HCC real IMbrave150. To further analyze efficacy bevacizumab, prospective should include heterogeneous patient groups.
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ژورنال
عنوان ژورنال: ?????????? ???????? ? ?????????
سال: 2023
ISSN: ['2076-3093', '2307-0501']
DOI: https://doi.org/10.24060/2076-3093-2023-13-2-131-142