Atezolizumab and Bevacizumab in Therapy for Patients with Hepatocellular Carcinoma in Real Clinical Practice

نویسندگان

چکیده

Randomized clinical trials and actual practice differsignificantly. Evidence-based medicine develops new agents referring to, primarily, pharmaceutical findings, preclinical studies and, most importantly, randomized trials. Hepatocellular carcinoma is the common primary malignancy of liver, one main causes fatal outcomes among cancer patients worldwide, including in Asia-Pacific region, with an estimated 800,000 deaths annually. For more than 10 years, sorafenib, a tyrosine kinase inhibitor, was only authorized treatment for advanced hepatocellular carcinoma. The next stage development drug therapy involved immune checkpoint inhibitors. combination atezolizumab bevacizumab phase III trial (IMbrave150) improved carcinoma, such as overall survival progression-free (6.8 versus 4.3). paper presents combination, demonstrates comparable data on HCC real IMbrave150. To further analyze efficacy bevacizumab, prospective should include heterogeneous patient groups.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

transcatheter arterial chemoembolization therapy for patients with unresectable hepatocellular carcinoma

conclusions we showed that in treatment of patients with unresectable hepatocellular carcinoma, tace significantly improved the disease and the overall survival rate. also, we introduce the tumor size, serum alp level, and number of liver involved segments as prognostic factors of the procedure. finally, tace can be recommended as the initial treatment for unresectable hcc patients. background ...

متن کامل

Status of serum alpha feto-protein (AFP) and midkine (MDK) levels in patients with hepatocellular carcinoma

Introduction: Hepatocellular carcinoma (HCC) is sixth common cancers worldwide and predominant in Asia and Africa. A number of evidence suggests a possible role of midkine (MDK) and α-fetoprotein (AFP) in the pathogenesis of hepatocellular carcinoma (HCC). Materials and methods: We studied MDK and AFP in patients with HCC or in healthy controls. MDK and AFP was measured by enzyme linked immuno...

متن کامل

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma

Anti-tumour immune activation by checkpoint inhibitors leads to durable responses in a variety of cancers, but combination approaches are required to extend this benefit beyond a subset of patients. In preclinical models tumour-derived VEGF limits immune cell activity while anti-VEGF augments intra-tumoral T-cell infiltration, potentially through vascular normalization and endothelial cell acti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: ?????????? ???????? ? ?????????

سال: 2023

ISSN: ['2076-3093', '2307-0501']

DOI: https://doi.org/10.24060/2076-3093-2023-13-2-131-142